Cheap, Easily Synthesized Anthelmintic Medicine: Fenbendazole

The amount of fenbendazole to be taken on a daily basis may differ based on the patient’s health status as well as any accompanying drugs and/or chemotherapy treatments.

It is important to speak with a licensed medical professional who is experienced in both traditional chemotherapeutic and alternative cancer treatments and medication reconciliation before combining fenbendazole with chemotherapy, additional supplements, natural products, nutraceuticals, or pharmaceuticals not related to cancer treatment, or taking fenbendazole alone to treat cancer to avoid potential adverse effects.

The storage conditions for fenbendazole powder, capsules, and tablets should be kept below 25 °C, out of direct sunlight. The toxicity, genotoxicity, and carcinogenicity of fenbendazole are not well known since it is not intended for human use and there is no record of prior human-use. Furthermore, it is hard to predict what side effects may occur when other medications are ingested alongside fenbendazole.

It has been established that the acute toxicity of fenbendazole when ingested orally is minimal. No maximum intake limit has been determined as it is likely that the threshold for toxicity lies beyond 5000 mg of material for each kilogram of body weight. A number of human trials involving subjects taking up to 500 mg and 2,000 mg of the material have been conducted with no observed negative effects. Furthermore, European Medicines Agency-sponsored genotoxicity tests have not revealed any genotoxicity. A two-year study on mice showed no evidence of carcinogenicity. These data on toxicity, genotoxicity, and carcinogenicity have been retrieved.

The potential negative impacts of this treatment may include vomiting (although it is uncommon), diarrhea (also uncommon), jaundice (very uncommon), itching of the skin (also very uncommon), injury to the liver (extremely rare) and changes to metabolism.

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Following absorption, fenbendazole undergoes two transformation steps in the body: hydroxylation and oxidation. Liver enzymes CYP2J2 and CYP2C19 catalyze the hydroxylation process, which produces the metabolite hydroxyfenbendazole. Oxidation of the sulfide group, performed by the liver enzymes CYP3A and flavin-containing monooxygenase, produces the compound oxfendazole, which demonstrates antineoplastic and anthelmintic activities.

It appears that fenbendazole serves both as a drug and a prodrug, leading to the production of another active medication. Unfortunately, not much of the substance is absorbed through the intestines and a small amount is excreted with feces. Of note, CYP2C19, an enzyme utilized to metabolize fenbendazole, is also used to break down drugs such as tamoxifen, ebastine, amiodarone, astemizole, mesoridazine, apixaban, thioridazine, and cyclosporine.

A cancer patient should talk to a doctor before taking fenbendazole powder with any other medications, to learn about reactions between the drugs, further adverse reactions and the potential for increased toxicity. Visit: 

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